Scrum-half Gareth Davies makes his first start for the Scarlets as the Pro12 leaders travel to Ireland to face Leinster at the RDS.
Wales teammate Ken Owens drops to the bench with Emyr Phillips taking his place at hooker.
Centre Gareth Owen and wing Michael Tagicakibau return from injury for the west Walians as the region look to continue their perfect start to the season.
The Llanelli outfit have won six matches out of six to send them top of the table at this early stage of the season.
But the match against Leinster will be a real test of their credentials.
The Scarlets did beat their opponents at Parc y Scarlets just a few weeks ago, with DTH van der Merwe scoring twice on his debut in a 25-14 victory.
But the Canadian flyer has been rested following his World Cup exerts and will miss the rematch in Dublin.
And the Leinster team which went down in Llanelli was devoid of many Ireland international who return for this encounter.
Leinster coach Leo Cullen hands starts to a number of internationals such as Rob Kearney, Zane Kirchner, Ian Madigan and Jamie Heaslip.
Jonny Sexton – back from his French adventure with Racing 92 – will start from the replacements bench.
Leinster: Rob Kearney; Zane Kirchner, Garry Ringrose, Noel Reid, Cian Kelleher; Ian Madigan, Isaac Boss; Cian Healy, James Tracy, Mike Ross; Devin Toner, Tom Denton; Dominic Ryan, Sean O’Brien, Jamie Heaslip (capt).
Replacements: Bryan Byrne, Jack McGrath, Marty Moore, Hayden Triggs, Dan Leavy, Luke McGrath, Jonny Sexton, Ben Te’o.
Scarlets: Aled Thomas; Tom Williams, Gareth Owen, Hadleigh Parkes, Michael Tagicakibau; Dan Jones, Gareth Davies, Rob Evans, Emyr Phillips, Peter Edwards, Jake Ball, Lewis Rawlins, Aaron Shingler, James Davies, John Barclay (capt).
Replacements: Ken Owens, Dylan Evans, Will Taylor, Tom Price, Maselino Paulino, Aled Davies, Michael Collins, Harry Robinson
