Saracens, the only side to go unbeaten in the pool stages, welcome back Chris Wyles to the left wing in what is an otherwise unchanged starting XV to the one that beat Bath 30-10 at the Rec last weekend.
Wyles will accompany Chris Ashton and Alex Goode in the back three whilst Brad Barritt -who captains the side- partners Duncan Taylor in the centres in what will be Saracens’ fifth consecutive European quarter-final.
Richard Wigglesworth will combine with fly-half Owen Farrell in the half-backs as the latter looks to add to his 73 Champions Cup points this season.
England loosehead Mako Vunipola will pack down alongside Schalk Brits and Petrous Du Plessis who play at hooker and tighthead prop respectively.
Saracens’ and England’s formidable second-row partnership of George Kruis and Maro Itoje continues whilst Billy Vunipola, arguably England’s most destructive player during their grand slam victory, starts at number eight with Jackson Wray (blindside flanker) and Will Fraser (openside flanker) featuring either side of him.
Whilst Saracens remain virtually unchanged for the first European quarter-final to be played at Allianz Park, Northampton Saints make a quintet of changes to the lineup that lost to Wasps last weekend.
Ben Foden will captain the side from full-back and will be joined by Ken Pisi and Jamie Elliott, who comes into the side to replace George North.
George Pisi remains at outside centre and is joined by Luther Burrell, coming into the side as Henry Mallinder is moved to the bench whilst Kahn Fotuali’i and Stephen Myler continue together at nine and 10 respectively.
Paul Hill comes into the side at tighthead, joining Mikey Haywood (hooker) and Alex Waller (loosehead) in the front row.
The introduction of James Craig in the second row alongside Christian Day sees Courteney Lawes shifted to blindside flanker where he accompanies Ben Nutley (openside flanker) and Teimana Harrison (number eight).
Speaking in the week, Mark McCall has said he is counting on Saracens’ extensive European experience to guide them to a victory over the Saints.
I think that over the four year period this is our fifth consecutive quarter-final, and during that period we have gained experience in the competition and played in a lot of knock-out matches in the competition.
Each year I think we’ve become a little bit stronger, a little bit better and the players that we have are more experienced than they’ve ever been playing in these big matches.
Saracens: 15 Alex Goode, 14 Chris Ashton, 13 Duncan Taylor, 12 Brad Barritt, 11 Chris Wyles, 10 Owen Farrell, 9 Richard Wigglesworth, 8 Billy Vunipola, 7 Will Fraser, 6 Jackson Wray, 5 George Kruis, 4 Maro Itoje, 3 Petrus du Plessis, 2 Schalk Brits, 1 Mako Vunipola
Replacements: 16 Jared Saunders, 17 Richard Barrington, 18 Titi Lamositele, 19 Alistair Hargreaves, 20 Michael Rhodes, 21 Neil de Kock, 22 Marcelo Bosch, 23 Ben Ransom
Northampton: 15 Ben Foden (c), 14 Ken Pisi, 13 George Pisi, 12 Luther Burrell, 11 Jamie Elliott, 10 Stephen Myler, 9 Kahn Fotuali’i, 8 Teimana Harrison, 7 Ben Nutley, 6 Courtney Lawes, 5 Christian Day, 4 James Craig, 3 Paul Hill, 2 Mikey Haywood, 1 Alex Waller
Replacements: 16 Reece Marshall, 17 Campese Ma’afu, 18 Gareth Denman, 19 Victor Matfield, 20 Michael Paterson, 21 Tom Kessell, 22 JJ Hanrahan, 23 Harry Mallinder